The sex of each individual was determined by the ratio of sequencing coverages on sex chromosomes versus autosomes (Supplementary Data 1.C). 15, 22792300 (2020). of Leiden, 2000). Dismiss. Nowadays, we take it for granted that these features exist, but the integrity of those products is, in fact, a labor of love. Your email address will not be published. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. This broadly distributed ancestry (the Oberkassel cluster (also known as WHG)) is most closely related to an Epigravettian-associated individual from northwestern Italy, suggesting that its expansion into continental Europe might have started from the westand not the eastside of the Alps. Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. I love learning new things a. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. Nat. These European regions, therefore, constitute climatic refugia where human populations survived during the LGM. Pseudo-haploid genotypes were called on the targeted SNPs by randomly sampling a single allele at each position, resulting in individuals with 6,600 to 1.07 million SNPs covered on the 1.24-million-SNP panel (Extended Data Table 1 and Supplementary Data 1.A). Science 346, 11131118 (2014). National Science Council feb. 2009 - feb. 2009 1 maand. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. 32, 17921797 (2004). USA 111, 22292234 (2014). When expanded it provides a list of search options that will switch the search inputs to match the current selection. As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. Int. 1 and 2). 14, evac045 (2022). B. et al. Svensson, E. et al. The Magdalenian culture was widely distributed in southwestern, western and central Europe after the LGM33. Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. Modern humans have populated Europe for more than 45,000 years 1, 2. Sci. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. Highly recommended for not only people preparing for interviews but for people that just want to improve their coding skills. Google Scholar. Photo by Sara Kurfe on Unsplash 1. Rohland, N. & Hofreiter, M. Ancient DNA extraction from bones and teeth. During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. In panel a, genetic affinity between different ancestries is indicated by thick lines or shades, while admixture is indicated with arrows. 13). Sci. C. Posth and H.Y. Thats exactly why choosing the right feature to build is so important! The Neolithic transition in the Baltic was not driven by admixture with early European farmers. Genome Biol. I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. Curr. Hi friends! By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. Article . A negative and cave bear positive controls were included. In practice, we use machine learning in different conjunctures. The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. By submitting a comment you agree to abide by our Terms and Community Guidelines. Sci. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. 1 MtDNA and Y-chromosome phylogenies. Interviewed Taiwanese designers and analyzed the interview data. We give some of our best tips to improve them and hopefully help you all land a data science interview. Nature (Nature) Google Scholar. Max Planck Institute for Evolutionary Anthropology. The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. CAS Wonderful course so far Tina. Brunel, S. et al. Jensen, T. Z. T. et al. Its like the different ingredients in your recipe. Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. Genomic structure in Europeans dating back at least 36,200 years. Tina is excellent when it comes to getting overall data science career advice. The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. Antonio, M. L. et al. PubMed Nature 570, 182188 (2019). Jones, E. R. et al. 27 and 28). Finally, unsupervised clustering and more complex techniques, such as deep learning, also have their place. SQL for Data Science Interviews . In our case, we had data about people who had fallen off the internet, and we wanted to predict the probability that they would fall off at a certain time. You are using a browser version with limited support for CSS. Lazaridis, I. et al. PubMed The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. Nat. Product development is a huge and complex set of processes that rests on many moving parts, lots of hypotheses testing, and ultimately many decisions. Biol. Protoc. However, additional genomes intermediate in time and space are needed to assess whether those two admixture events were independent or part of a common demographic process. Adapted from https://doi.org/10.5281/zenodo.5903165 (CC BY 4.0). Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). If you want to know more, you can always go to MySQLs data warehouse site. Youll be surprised how much value there is in a quick XGBoost model, for example. The IntCal20 Northern Hemisphere radiocarbon age calibration curve (055 cal kbp). Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. 2 The distribution of mtDNA and Y-chromosome haplogroups among different hunter-gatherer groups. Have any problems using the site? Jagwire Europe - Fevacom NV . I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. . performed mortuary practices analyses. First Name Tina. The suspension was then centrifuged and transferred into a binding buffer as previously described56. Ancient genomes indicate population replacement in Early Neolithic Britain. Le palolithique suprieur en Italie. The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. 3b). "Unlike diving into the university life directly, the pathways program is a buffer that allows international students to be better prepared. Taiwan. 2022 Weird Science Plus - All Rights Reserved. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. E.A. TV Actresses. The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). Tina Huang. Int. Citations 52. In product development, 80% of the success of a product is determined by 20% of its features. In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. Curr. 8). Large-scale genomic analysis documents the migrations of Ice Age hunter-gatherers over a period of 30,000 years -- they took shelter in Western Europe but died out on the . Ecol. Adv. 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. This study focuses on the people who lived between 35,000 and 5,000 years ago and that are, at least partially, the ancestors of the present-day population of Western Eurasia, including -- for the first time -- the genomes of people who lived during the Last Glacial Maximum (LGM), the coldest phase of the last Ice Age, around 25,000 years ago. Key, F. M. et al. The sequence alignment/map format and SAMtools. I Agree, Brandwatch Bulletin #41: 7 Women in Tech You ShouldKnow. Villalba-Mouco, V. et al. . Previously worked at Goldman Sachs and the Ontario Institute for . The x-axis shows the average age of each tested individual/group and the y-axis shows the proportion of Sidelkino ancestry, relative to the total hunter-gatherer ancestry (Oberkassel + Sidelkino) in each group. Ecol. & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Powered by Symplectic part of Digital Science . They, along with it, will be accessible to you indefinitely. Follow. Nat. 9). 3a and Supplementary Fig. . Details of the grouping and ROH segments are provided in Data S3.B. Ongoing symptoms 3 months after infection by SARS-CoV-2 are well described as long COVID and have become a global health concern [1], [2].Fatigue and dyspnea are the two most common symptoms after infection by SARS-CoV-2 and low physical performance impacting daily activities has been described for up to 6 months after infection [3]. October 28 Actress #31. Within Sicily, the 14ka Oriente C individual shows higher affinity with the much younger but geographically closer 10ka Uzzo group30 (n=2) than with the almost contemporaneous San Teodoro 2 individual from eastern Sicily. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. 3.Tina Huang. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. 27, 32023208.e9 (2017). Sci. Individuals from northwestern Italy (Arene Candide 16), central Italy (Continenza) and Sicily fall on a phylogenetically more derived branch (group 2), which further diversified into a branch composed of Sicilian hunter-gatherers only (group 3). Green, R. E. et al. We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). Int. Additional details are provided in SupplementaryInformation, section11 and SupplementaryTable 3. There is no biographical data to display. Cambridge Archaeol. Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. 2, e190 (2006). Tina Huang hellotinah@gmail.com | 123-456-7890 | 1 BeepbeepBoop St. Philadelphia, PA 19104 EDUCATION AND HONORS University of Internet Explorer). (Robert Rueda; Tina Saldivar; Lynne Shapiro; Shane Templeton; Houghton Mifflin Company Staff) 2022-112-4f84b - Ecologizr. This free online conference is featuring panel discussions from Amina is a software engineer, who is also an accessibility advocate and content creator. Details are provided in Data S2.B. Look here to get updated on my recent favourite books, animes, filming equipment and more! Genome of Petera Muierii skull shows high diversity and low mutational load in pre-glacial Europe. This is perfect for those of us who haven't a clue what to expect from data science - SQL portion - interviews. We also compared its affinity to El Mirn (northern Spain), the oldest Magdalenian-associated individual sequenced to date (19ka). Tina teaches SQL in data science in addition to this basic material. Natl Acad. This is in sharp contrast to the genetic history of Iberian hunter-gatherers, where the spread of the Villabruna/Oberkassel ancestry involved multiple local admixture events with groups carrying high proportions of GoyetQ2 ancestry14 (Fig. My name is Tina Huang and I'm a data scientist at a FAANG company. Science 363, 12301234 (2019). The indexed products for each library were pooled, purified over MinElute columns (Qiagen), eluted in 50l TET and again quantified using the IS5 and IS6 primers59 using the quantification method described above. PubMed Central Total students. Science 328, 710722 (2010). Showcase your skills and bolster your data science credentials. One of my favorite videos of her is where she talks about the resume that got her an entry-level data science job. But she came up with a way to break down the code and create a website that she was proud of. 1999 - 20001 year. She graduated with a degree in Computer Science and Applied Math. Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). We love meeting interesting people and making new friends. 7 and Supplementary Table 3), which coincides roughly with the first appearance of the Oberkassel ancestry in central Europe. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. We built a Maximum Parsimony tree with 103 mtDNA sequences plus an African sequence as the outgroup (not shown) after the removal of individuals younger than 6.5ka and mtDNAs from the same site with an identical placement. 5). and JavaScript. Both of these books focus on the science and math behind data mining. . First Name Tina #39. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Extended Data Fig. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). For the placement of individuals onto a Y-chromosomal phylogenetic tree (Extended Data Fig. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry. Her YouTube channel is dedicated to data and computer science, including how to educate yourself in these topics. Protoc. About me. Get the latest science news in your RSS reader with ScienceDaily's hourly updated newsfeeds, covering hundreds of topics: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Google Scholar. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. She then served as a postdoctoral associate at the National Institute of Standards and Technology. Dismiss. The previous inhabitants may have migrated to the north as their habitat, the 'mammoth' steppe, dwindled," says Johannes Krause, the study's senior author. Originally published at https://365datascience.com on October 1, 2020. Required fields are marked *. University Universit Chouaib Doukkali; . 211 and Supplementary Table 1). Nat. The ancient human specimens analysed in this work derive from multiple scientific collaborations. Bilateral trade between China and Russia in 2022 rose 34.3% year-on-year to a record high of 1.28 trillion yuan ($190 billion) in yuan-denominated terms, Chinese customs data showed in early January. Int. Korlevi, P. et al. Tina is a data scientist working in tech and does Youtube part time. Anti Slip Coating UAE CAS Shes currently at Microsoft. 27 and 28 and Supplementary Data 3.G. This raises the possibility that the replacement by the Oberkassel cluster and the formation of the Sidelkino cluster might have been the result of population expansions influenced by the abrupt warming during the BllingAllerd interstadial4,24. 14 following. Greater San Diego Area. 1). Moreover, the almost complete genetic replacement of the Magdalenian-associated gene pool raises the hypothesis that parts of Europe were differentially populated during the abrupt climatic variation starting around 14.7ka with the BllingAllerd warming period, creating areas where southern European populations could expand. With a lot of raw data, you need to put in some work. Tina is a computer science student at Stanford University. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. 1.Introduction. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). 4 Admixture graph modelling of pre-34 ka hunter-gatherer lineages. Tina Huang. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. Article The libraries underwent shallow shotgun sequencing on an Illumina HiSeq 4000 instrument with 75 single-end-run cycles using the manufacturers protocol, to evaluate the human endogenous DNA content and quality. This may have prompted people from the south to expand their habitat. In addition to her data science work, Tina has also created the popular popular game Code Wars.
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